Current and Filled Pathway Holes of <i>Pseudomonas aeruginosa</i> PAO1

Current and Filled Pathway Holes of Pseudomonas aeruginosa PAO1

A pathway hole is a pathway reaction for which no corresponding enzyme has been identified in the genome. We consider only contiguous pathways (pathways containing connected sets of reactions, as opposed to pathways containing unconnected sets of reactions) when enumerating pathway holes.

This report includes two tables regarding pathway holes in Pseudomonas aeruginosa PAO1:

Current Pathway Holes: A list of reactions within metabolic pathways of Pseudomonas aeruginosa PAO1 for which no corresponding enzyme has been found.

Filled Pathway Holes: A list of former pathway holes within metabolic pathways of Pseudomonas aeruginosa PAO1 which have been filled with the assistance of the Pathway Hole Filler.


Current Pathway Holes

This table lists reactions within metabolic pathways of Pseudomonas aeruginosa PAO1 for which no corresponding enzyme has been identified in the genome. The presence of those enzymes is suggested by the presence of the pathway.

69 pathway holes (8.9%) are present in the 775 total reactions of 236 pathways

Reaction EC# Pathway(s) needing this reaction
S-ribosyl-L-homocysteine → L-homocysteine + autoinducer 2 4.4.1.21 S-adenosyl-L-methionine cycle I
S-adenosyl-L-homocysteine + H2O → S-ribosyl-L-homocysteine + adenine 3.2.2.9 S-adenosyl-L-methionine cycle I
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+ ← L-erythro-7,8-dihydrobiopterin + NADH + H+ 1.5.1.- L-phenylalanine degradation I (aerobic)
thiamine + ATP → thiamine phosphate + ADP + H+ 2.7.1.89 thiamine salvage I
acetaldehyde + coenzyme A + NAD+ → acetyl-CoA + NADH + H+ 1.2.1.10 2-aminoethylphosphonate degradation I
citronellate + coenzyme A + ATP → citronellyll-CoA + AMP + diphosphate 6.2.1.- citronellol degradation
citronellal + oxidized electron carrier + H2O → citronellate + reduced two electron carrier + H+ 1.1.99.- citronellol degradation
citronellol + oxidized electron carrier → citronellal + reduced two electron carrier 1.1.99.- citronellol degradation
ATP + β-D-fructofuranose 6-phosphate → ADP + β-D-fructose 1,6-bisphosphate + H+ 2.7.1.11 glycolysis I (from glucose 6-phosphate)
L-tyrosine + S-adenosyl-L-methionine + NADPH → 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+ 4.1.99.19 thiazole biosynthesis I (facultative anaerobic bacteria)
[ThiS sulfur-carrier protein] + ATP + H+ → carboxy-adenylated-[ThiS sulfur-carrier protein] + diphosphate 2.7.7.73 thiazole biosynthesis I (facultative anaerobic bacteria)
2-(acetamidomethylene)succinate + H+ + 2 H2O → ammonium + CO2 + succinate semialdehyde + acetate 3.5.1.29 vitamin B6 degradation
3-hydroxy-2-methylpyridine-4,5-dicarboxylate + H+ → CO2 + 3-hydroxy-2-methylpyridine-5-carboxylate 4.1.1.51 vitamin B6 degradation
5-formyl-3-hydroxy-2-methylpyidine-4-carboxylate + oxidized electron carrier + H2O → 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + oxidized electron carrier + reduced two electron carrier + H+ [none] vitamin B6 degradation
4-pyridoxate + oxidized electron carrier → 5-formyl-3-hydroxy-2-methylpyidine-4-carboxylate + reduced two electron carrier [none] vitamin B6 degradation
4-pyridoxolactone + H2O → 4-pyridoxate + H+ 3.1.1.27 vitamin B6 degradation
pyridoxine + oxygen → hydrogen peroxide + pyridoxal 1.1.3.12 vitamin B6 degradation
pyruvate + pyridoxamine → L-alanine + pyridoxal 2.6.1.30 vitamin B6 degradation
L-tryptophan + oxygen → (indol-3-yl)acetamide + CO2 + H2O 1.13.12.3 indole-3-acetate biosynthesis III (bacteria)
D-xylopyranose ↔ D-xylulose 5.3.1.5 xylose degradation I
demethylated methyl acceptor + S-adenosyl-L-methionine ↔ S-adenosyl-L-homocysteine + methylated methyl acceptor + H+ 2.1.1.- L-methionine degradation I (to L-homocysteine), S-adenosyl-L-methionine cycle II, S-adenosyl-L-methionine cycle I
ferroheme i + reduced two electron carrier + oxygen → hydroxyferroheme i + oxidized electron carrier + H2O [none] heme a biosynthesis
ferroheme o + reduced two electron carrier + oxygen → ferroheme i + oxidized electron carrier + H2O [none] heme a biosynthesis
3-hydroxy-4-methylbenzaldehyde + NADP+ + H2O → 3-hydroxy-4-methyl-benzoate + NADPH + 2 H+ 1.2.1.7 2,5-xylenol and 3,5-xylenol degradation
2,5-xylenol + NADH + oxygen + H+ → 5-(hydroxymethyl)-2-methylphenol + NAD+ + H2O 1.14.13.- 2,5-xylenol and 3,5-xylenol degradation
3-hydroxy-5-methylbenzaldehyde + NADP+ + H2O → 3-hydroxy-5-methyl-benzoate + NADPH + 2 H+ 1.2.1.7 2,5-xylenol and 3,5-xylenol degradation
3,5-xylenol + NADH + oxygen + H+ → 3-(hydroxymethyl)-5-methylphenol + NAD+ + H2O 1.14.13.- 2,5-xylenol and 3,5-xylenol degradation
a chitodextrin + n H2O → n N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose 3.2.1.202 chitin degradation II (Vibrio)
α-D-glucosamine 6-phosphate + H2O ↔ β-D-fructofuranose 6-phosphate + ammonium 3.5.99.6 N-acetylglucosamine degradation I
vanillin + NAD+ + H2O → vanillate + NADH + 2 H+ 1.2.1.67 vanillin and vanillate degradation I
4-deoxy-4-formamido-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + H2O → 4-amino-4-deoxy-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + formate [none] polymyxin resistance
aminomethylphosphonate + acetyl-CoA → 2-N-acetamidomethylphosphonate + coenzyme A 2.3.1.- aminomethylphosphonate degradation
isopentenyl diphosphate ↔ dimethylallyl diphosphate 5.3.3.2 trans, trans-farnesyl diphosphate biosynthesis
dodecanoyl-[acp] + H2O → acyl-carrier protein + laurate + H+ 3.1.2.21 palmitate biosynthesis II (bacteria and plants)
cis-3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O → cis-3,4-dehydroadipyl-CoA + NADPH + 2 H+ 1.2.1.77 benzoyl-CoA degradation I (aerobic)
2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O → cis-3,4-dehydroadipyl-CoA semialdehyde + formate + H+ 4.1.2.44 benzoyl-CoA degradation I (aerobic)
cis-3,4-dehydroadipyl-CoA → trans-2,3-dehydroadipyl-coA 5.3.3.- benzoyl-CoA degradation I (aerobic)
benzoyl-CoA + NADPH + H+ + oxygen → 2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP+ + H2O 1.14.13.208 benzoyl-CoA degradation I (aerobic)
phenylacetate + ATP + coenzyme A → phenylacetyl-CoA + AMP + diphosphate 6.2.1.30 phenylacetate degradation I (aerobic)
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O → 3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ 1.2.1.91 phenylacetate degradation I (aerobic)
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O ↔ 3-oxo-5,6-didehydrosuberyl-CoA semialdehyde 3.3.2.12 phenylacetate degradation I (aerobic)
N,N-dimethylglycine + a tetrahydrofolate + oxidized electron-transfer flavoprotein + H+ → sarcosine + a 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein 1.5.8.4 glycine betaine degradation I
acrylamide ← acrylonitrile + H2O 4.2.1.84 acrylonitrile degradation I
7,8-dihydroneopterin 3'-triphosphate + H2O → 7,8-dihydroneopterin 3'-phosphate + diphosphate + H+ 3.6.1.67 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
7,8-dihydroneopterin 3'-phosphate + H2O → 7,8-dihydroneopterin + phosphate 3.6.1.- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
[cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex + 2 Fe3+ → [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex [none] [2Fe-2S] iron-sulfur cluster biosynthesis
α-D-glucopyranose 1-phosphate ↔ D-glucopyranose 6-phosphate 5.4.2.2 glycogen biosynthesis I (from ADP-D-Glucose)
α-D-glucopyranose 1-phosphate + ATP + H+ → ADP-α-D-glucose + diphosphate 2.7.7.27 glycogen biosynthesis I (from ADP-D-Glucose)
guanosine + H2O → D-ribofuranose + guanine 3.2.2.1 guanine and guanosine salvage II
alginate → n 4-deoxy-α-L-erythro-hex-4-enopyranuronate-α-L-guluronate 4.2.2.11 alginate degradation
2-dehydro-3-deoxy-D-gluconate + NADP+ ← (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H+ 1.1.1.126 alginate degradation
a 4-deoxy-α-L-erythro-hex-4-enopyranuronosyl-[oligosaccharide] → n 4-deoxy-L-erythro-hex-4-enopyranuronate 4.2.2.26 alginate degradation
5-methyl-3-oxo-4-hexenoyl-CoA + coenzyme A → 3-methylcrotonyl-CoA + acetyl-CoA 2.3.1.- cis-genanyl-CoA degradation
3-hydroxy-5-methylhex-4-enoyl-CoA + oxidized electron carrier → 5-methyl-3-oxo-4-hexenoyl-CoA + reduced two electron carrier 1.1.1.- cis-genanyl-CoA degradation
(2E)-5-methylhexa-2,4-dienoyl-CoA + H2O → 3-hydroxy-5-methylhex-4-enoyl-CoA 4.2.1.- cis-genanyl-CoA degradation
5-methylhex-4-enoyl-CoA + oxidized electron carrier → (2E)-5-methylhexa-2,4-dienoyl-CoA + reduced two electron carrier 1.3.99.- cis-genanyl-CoA degradation
7-methyl-3-oxooct-6-enoyl-CoA + coenzyme A → 5-methylhex-4-enoyl-CoA + acetyl-CoA 2.3.1.- cis-genanyl-CoA degradation
3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H+ → (R)-3-amino-2-methylpropanoate + ammonium + CO2 3.5.1.6 thymine degradation
(S)-malate + NAD+ ↔ oxaloacetate + NADH + H+ 1.1.1.37 TCA cycle I (prokaryotic), partial TCA cycle (obligate autotrophs), glyoxylate cycle, gluconeogenesis I
ferribactin + NADP+ + oxygen → pyoverdine I + NADPH + H2O + H+ 1.14.13.- pyoverdine I biosynthesis
6-(2-amino-2-carboxylatoethyl)-7-hydroxy-8-oxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + oxidized electron carrier → 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline 2,4-dicarboxylate + reduced two electron carrier 1.1.99.- pyrroloquinoline quinone biosynthesis
6-(2-amino-2-carboxylatoethyl)-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate + oxygen → 6-(2-amino-2-carboxylatoethyl)-7-hydroxy-8-oxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate [none] pyrroloquinoline quinone biosynthesis
N-ethylammeline + H+ + H2O → N-ethylammelide + ammonium [none] deethylsimazine degradation
a 5-methyltetrahydrofolate + 2 oxidized ferredoxin [iron-sulfur] cluster ← a 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ 1.5.7.1 folate transformations I
a tetrahydrofolate + trimethyl sulfonium ← dimethyl sulfide + a 5-methyltetrahydrofolate + H+ 2.1.1.19 folate transformations I
selenodiglutathione + NADPH + H+ → glutathioselenol + glutathione + NADP+ 1.8.1.- selenate reduction
hydrogen selenide + glutathione + NADP+ ← glutathioselenol + NADPH + H+ 1.8.1.- selenate reduction
selenite + AMP + glutathione disulfide + 3 H+ ← adenosine 5'-phosphoselenate + 2 glutathione 1.8.4.9 selenate reduction
oxidized thioredoxin + reduced two electron carrier ← reduced thioredoxin + oxidized electron carrier [none] thioredoxin pathway

Filled Pathway Holes

Key:
Hole-filler The gene whose product is predicted to catalyze the missing reaction.
Hole EC# The EC number of the missing reaction (links to the reaction page).
P(has-function) The probability that the hole-filler catalyzes the missing reaction as determined by the PHFiller.
All functions of hole-filler All current annotations of the hole-filler, including the function of the missing reaction to which it has been assigned.
Pathway(s) requiring this reaction All metabolic pathways in which the pathway hole occurs in the database.

07:36:29 on Thursday, 9/18/2025 (GMT-8)

128 pathway holes have been filled by the pathway hole filler, in 236 pathways.

Hole-filler Hole EC# P(has-function) All functions of hole-filler Pathway(s) requiring this reaction
pqsC none 1.000 hypothetical protein 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
pqsC none 1.000 hypothetical protein 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
pqsC none 1.000 hypothetical protein 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
pqsD none 1.000 3-oxoacyl-ACP synthase 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
pqsD none 1.000 3-oxoacyl-ACP synthase 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
pqsE 3.1.2.32 1.000 thioesterase PqsE 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
PA1140 3.5.3.26 0.956 hypothetical protein allantoin degradation to ureidoglycolate II (ammonia producing)
PA1280 3.1.3.73 0.999 hypothetical protein adenosylcobalamin salvage from cobinamide I
PA1280 5.4.2.11 0.996 hypothetical protein glycolysis I (from glucose 6-phosphate)
PA0142 3.8.1.8 1.000 8-oxoguanine deaminase atrazine degradation I (aerobic)
gbuA 3.5.3.24 0.914 guanidinobutyrase spermidine biosynthesis III
gbuA 3.5.3.1 0.940 guanidinobutyrase urea cycle
PA0148 3.5.4.31 0.914 adenosine deaminase S-methyl-5'-thioadenosine degradation III
PA1499 2.7.1.165 1.000 hypothetical protein glycolate and glyoxylate degradation I
PA1516 4.1.1.97 0.998 hypothetical protein urate conversion to allantoin I
PA1574 2.4.2.1 0.914 hypothetical protein adenosine nucleotides degradation II
PA1574 2.4.2.1 0.914 hypothetical protein xanthine and xanthosine salvage, inosine 5'-phosphate degradation
sdhA 1.3.5.4 1.000 succinate dehydrogenase flavoprotein subunit partial TCA cycle (obligate autotrophs)
PA1629 5.3.3.18 0.999 enoyl-CoA hydratase phenylacetate degradation I (aerobic)
acnB 4.2.1.99 0.999 aconitate hydratase B 2-methylcitrate cycle I
folD 1.5.1.15 1.000 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase folate transformations I
folD 6.3.4.3 0.982 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase folate transformations I, formate assimilation into 5,10-methylenetetrahydrofolate, folate polyglutamylation
fabI 1.3.1.10/1.3.1.39/1.3.1.104/2.3.1.85/2.3.1.86 0.999 NADH-dependent enoyl-ACP reductase fatty acid elongation -- saturated
phzB2 none 0.999 phenazine biosynthesis protein PhzB phenazine-1-carboxylate biosynthesis
phzB2 none 0.999 phenazine biosynthesis protein PhzB phenazine-1-carboxylate biosynthesis
pqqF none 0.964 coenzyme PQQ synthesis protein F pyrroloquinoline quinone biosynthesis
pqqE none 1.000 coenzyme PQQ synthesis protein E pyrroloquinoline quinone biosynthesis
maiA 5.2.1.2 1.000 maleylacetoacetate isomerase L-tyrosine degradation I
liuC 4.2.1.18 0.999 gamma-carboxygeranoyl-CoA hydratase L-leucine degradation I
PA2105 2.3.1.30 1.000 acetyltransferase L-cysteine biosynthesis I
bkdA2 1.2.1.- 0.982 2-oxoisovalerate dehydrogenase subunit beta L-isoleucine degradation I
bkdA2 1.2.1.- 0.982 2-oxoisovalerate dehydrogenase subunit beta L-leucine degradation I
pcaF 2.3.1.223 1.000 beta-ketoadipyl CoA thiolase phenylacetate degradation I (aerobic)
PA2261 2.7.1.45/2.7.1.178 0.956 2-ketogluconate kinase alginate degradation
PA2265 1.1.1.43 1.000 gluconate dehydrogenase glucose degradation (oxidative)
arsB 3.6.3.16 0.999 arsenite-antimonite efflux pump ArsB arsenate detoxification II (glutaredoxin)
gcd 1.1.5.2 0.999 glucose dehydrogenase glucose degradation (oxidative)
mtlD 1.1.1.11 1.000 mannitol dehydrogenase D-arabitol degradation
pvdA 1.14.13.195 0.999 L-ornithine N5-oxygenase pyoverdine I biosynthesis
pvdL 6.3.2.- 0.973 peptide synthase pyoverdine I biosynthesis
aroE 1.1.1.282 1.000 shikimate dehydrogenase chorismate biosynthesis from 3-dehydroquinate
PA2471 3.7.1.23 0.906 hypothetical protein 2,5-xylenol and 3,5-xylenol degradation
PA2471 3.7.1.23 0.906 hypothetical protein 2,5-xylenol and 3,5-xylenol degradation
PA2554 1.1.1.178 0.988 short-chain dehydrogenase L-isoleucine degradation I
pqsH 1.14.12.4 0.914 2-heptyl-3-hydroxy-4(1H)-quinolone synthase vitamin B6 degradation
PA0266 2.6.1.19 0.999 5-aminovalerate aminotransferase DavT 4-aminobutanoate degradation I
PA0266 2.6.1.22 0.914 5-aminovalerate aminotransferase DavT L-valine degradation I
tesA 3.1.2.14 0.972 esterase TesA palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
cobJ 2.1.1.131 0.999 precorrin-3 methylase CobJ cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
cobI 2.1.1.152 0.964 precorrin-2 C(20)-methyltransferase cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
PA2906 1.14.13.83 0.999 oxidoreductase cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
cobL none 1.000 precorrin-6y-dependent methyltransferase CobL cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
cobL none 1.000 precorrin-6y-dependent methyltransferase CobL cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
PA2950 1.3.1.9 1.000 reductase gondoate biosynthesis (anaerobic)
PA2950 1.3.1.9 1.000 reductase stearate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitate biosynthesis II (bacteria and plants)
PA2950 1.3.1.9 1.000 reductase palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
PA2950 1.3.1.9 1.000 reductase palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
PA3004 2.4.2.1/2.4.2.15 0.964 S-methyl-5'-thioinosine phosphorylase guanine and guanosine salvage, guanosine nucleotides degradation III
mobA none 1.000 molybdenum cofactor guanylyltransferase bis(guanylyl molybdenum cofactor) biosynthesis
gltX 6.1.1.24 0.989 glutamate--tRNA ligase glutaminyl-tRNAgln biosynthesis via transamidation
PA3139 2.6.1.3 0.988 aspartate aminotransferase hydrogen sulfide biosynthesis I
PA3242 2.3.1.243 1.000 lipid A biosynthesis lauroyl acyltransferase superpathway of (Kdo)2-lipid A biosynthesis, (Kdo)2-lipid A biosynthesis I
PA3372 3.1.4.55 1.000 carbon-phosphorus lyase complex accessory protein aminomethylphosphonate degradation
PA3373 2.7.4.23 1.000 hypothetical protein aminomethylphosphonate degradation
PA3374 3.6.1.63 1.000 hypothetical protein aminomethylphosphonate degradation
PA3379 2.7.8.37 1.000 carbon-phosphorus lyase complex subunit aminomethylphosphonate degradation
PA3471 1.1.1.40 1.000 NAD-dependent malic enzyme gluconeogenesis I
algA 2.7.7.13 1.000 bifunctional mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase GDP-mannose biosynthesis
arnA 1.1.1.305 1.000 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase polymyxin resistance
PA3568 6.2.1.17 0.973 propionyl-CoA synthetase 2-methylcitrate cycle I
adhC 1.1.1.90 0.972 alcohol dehydrogenase 2,5-xylenol and 3,5-xylenol degradation
adhC 1.1.1.90 0.972 alcohol dehydrogenase 2,5-xylenol and 3,5-xylenol degradation
PA3649 3.4.21.- 0.988 zinc metalloprotease lipoprotein posttranslational modification
hscA 3.6.4.- 0.999 chaperone protein HscA [2Fe-2S] iron-sulfur cluster biosynthesis
hscB none 0.918 co-chaperone HscB [2Fe-2S] iron-sulfur cluster biosynthesis
iscU none 1.000 scaffold protein [2Fe-2S] iron-sulfur cluster biosynthesis
dauB 1.4.1.25 0.999 NAD(P)H-dependent anabolic L-arginine dehydrogenase DauB D-arginine degradation
lnt 2.3.1.- 0.975 apolipoprotein N-acyltransferase lipoprotein posttranslational modification
ispA 2.5.1.1 1.000 geranyltranstransferase trans, trans-farnesyl diphosphate biosynthesis
ribD 1.1.1.193 1.000 riboflavin-specific deaminase/reductase flavin biosynthesis I (bacteria and plants)
PA4100 1.1.99.- 0.995 dehydrogenase octane oxidation
PA4122 4.1.1.68 0.934 hypothetical protein 4-hydroxyphenylacetate degradation
hpcC 1.2.1.60 1.000 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase 4-hydroxyphenylacetate degradation
phzD1 3.3.2.15 1.000 phenazine biosynthesis protein PhzD phenazine-1-carboxylate biosynthesis
phzE1 2.6.1.86 0.998 phenazine biosynthesis protein PhzE phenazine-1-carboxylate biosynthesis
phzG1 1.10.3.16 1.000 pyridoxamine 5'-phosphate oxidase phenazine-1-carboxylate biosynthesis
phzG1 1.10.3.16 1.000 pyridoxamine 5'-phosphate oxidase phenazine-1-carboxylate biosynthesis
phzG1 1.10.3.16 1.000 pyridoxamine 5'-phosphate oxidase phenazine-1-carboxylate biosynthesis
phzG1 1.10.3.16 1.000 pyridoxamine 5'-phosphate oxidase phenazine-1-carboxylate biosynthesis
phzS 1.14.13.24 0.956 hypothetical protein 2,5-xylenol and 3,5-xylenol degradation
phzS 1.14.13.24 0.956 hypothetical protein 2,5-xylenol and 3,5-xylenol degradation
phzS 1.14.13.218 0.999 hypothetical protein pyocyanin biosynthesis
pchC 3.1.2.14 0.914 pyochelin biosynthetic protein PchC stearate biosynthesis II (bacteria and plants)
pchC 3.1.2.14 0.914 pyochelin biosynthetic protein PchC palmitate biosynthesis II (bacteria and plants)
metF 1.5.1.20 0.956 5,10-methylenetetrahydrofolate reductase folate transformations I, N10-formyl-tetrahydrofolate biosynthesis
codA 3.5.4.42 0.956 cytosine deaminase atrazine degradation I (aerobic)
PA0439 1.3.1.2 1.000 dihydropyrimidine dehydrogenase thymine degradation
dht 3.5.2.5 0.998 D-hydantoinase/dihydropyrimidinase allantoin degradation to ureidoglycolate II (ammonia producing)
murA 2.5.1.19 0.980 UDP-N-acetylglucosamine 1-carboxyvinyltransferase chorismate biosynthesis from 3-dehydroquinate
PA4458 3.1.3.45 0.998 hypothetical protein CMP-3-deoxy-D-manno-octulosonate biosynthesis
folP 2.5.1.15 1.000 dihydropteroate synthase tetrahydrofolate biosynthesis
dnaK none 0.999 molecular chaperone DnaK [2Fe-2S] iron-sulfur cluster biosynthesis
dnaK none 0.999 molecular chaperone DnaK [2Fe-2S] iron-sulfur cluster biosynthesis
PA4899 1.2.1.3 0.999 aldehyde dehydrogenase octane oxidation
rnr 3.1.13.1 1.000 exoribonuclease R tRNA processing
PA4950 1.17.99.6 1.000 hypothetical protein queuosine biosynthesis
waaA 2.4.99.13 1.000 3-deoxy-D-manno-octulosonic acid transferase Kdo transfer to lipid IVA I
thiI 2.8.1.- 0.999 thiamine biosynthesis protein ThiI thiazole biosynthesis I (facultative anaerobic bacteria)
hisB 3.1.3.15 1.000 imidazoleglycerol-phosphate dehydratase L-histidine biosynthesis
ppx 3.6.1.40 1.000 exopolyphosphatase ppGpp biosynthesis
PA5281 3.1.3.104 0.956 hydrolase flavin biosynthesis I (bacteria and plants)
glcF 1.1.99.14 0.999 glycolate oxidase iron-sulfur subunit glycolate and glyoxylate degradation I
gbcB 1.14.13.149 0.956 protein GbcB phenylacetate degradation I (aerobic)
soxB 1.5.3.1 1.000 sarcosine oxidase subunit beta glycine betaine degradation I
gcp 2.3.1.234 1.000 tRNA N6-adenosine threonylcarbamoyltransferase N6-L-threonylcarbamoyladenosine37-modified tRNA biosynthesis
PA0744 3.1.2.4 1.000 enoyl-CoA hydratase L-valine degradation I
PA0746 1.3.8.- 0.999 acyl-CoA dehydrogenase L-valine degradation I
PA0746 1.3.8.5 0.999 acyl-CoA dehydrogenase L-isoleucine degradation I
aruC 2.6.1.81 1.000 acetylornithine aminotransferase L-arginine degradation II (AST pathway)
relA 3.1.7.2 1.000 GTP pyrophosphokinase ppGpp biosynthesis
PA0975 4.3.99.3 1.000 radical activating enzyme preQ0 biosynthesis

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